In organic synthesis, 2, 6-lutidine is thus widely used as a sterically hindered mild base.
2.
2, 6-Lutidine is weakly nucleophilic, due to the steric effects of the two methyl groups on the ring nitrogen.
3.
The unsubstituted pyridine ring degrades more rapidly than picoline, lutidine, chloropyridine, or aminopyridines, and a number of pyridine degraders have been shown to overproduce riboflavin in the presence of pyridine.
4.
The amide group is reprotected as BOC "'6 "'and the azide group converted to the amide "'7 "'by reductive acylation with thioacetic acid and 2, 6-lutidine.
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