Examples of heptoses include the ketose s mannoheptulose and sedoheptulose.
2.
Mannoheptulose has been reported to inhibit insulin secretion from pancreas.
3.
It is found as D-mannoheptulose in avocados.
4.
Experiments with rats have indicated that D-mannoheptulose injections created an aversion to carbohydrates.
5.
However, while mannoheptulose is suggested to affect the energy balance of adult dogs, independent of dosage and physical activity, research disagrees whether it significantly alters energy expenditure in dogs.
6.
This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited ( because there is no production of glucose-6-P ) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.
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