1. Thrombopoietin stimulates megakaryopoiesis, the process of megakaryocyte maturation and differentiation. 2. The development of megakaryocytes is in turn governed by two protein hormones. 3. The cell eventually reaches megakaryocyte stage and loses its ability to divide. 4. It drives red blood cell differentiation and represses megakaryocyte formation. 5. Platelets are derived from blood cells known as megakaryocytes . 6. It's known as megakaryocyte growth and development factor, or MGDF. 7. Macrophages remove senescent erythrocytes, leukocytes, and megakaryocytes by phagocytosis and digestion. 8. In megakaryocytes , it is regulated by the GATA-1 transcription factor. 9. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. 10. Both early and late in disease, megakaryocytes are often prominent and are usually dysplastic.
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