Neurotmesis is classified under the Seddon system which is defined by three grades of nerve injury.
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Neurotmesis is diagnosed through clinical evaluation of symptoms, physical evaluation, and other diagnostic studies.
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In Seddon's Classification, nerve injury is described as either neurapraxia, axonotmesis, or neurotmesis.
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Neurapraxia results in temporary damage to the nerve conduction has been restored; otherwise, the injury would be classified as axonotmesis or neurotmesis.
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The last and most severe case of peripheral nerve injury is known as neurotmesis, which in most cases cannot be completely recovered from even with surgical repair.
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The table at the right details the forms ( neurapraxia, axonotmesis and neurotmesis ) and degrees of nerve injury that occur as a result of exposure to various temperatures.
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This classification uses five different degrees of nerve injury, the first one being the least severe and the equivalent to neurapraxia and the most severe being the fifth degree and having the same classification as neurotmesis.
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Cryoneurolysis treatments which utilize liquid nitrogen ( boiling point of-195.8 �C ) as the coolant fall into the range of a neurotmesis injury, or 3rd degree injury according to the Sunderland classification.
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