1. It is thought that some oxaziridines racemize over time through a nitrone intermediate. 2. This cycloaddition between a nitrone and a cyclooctyne forms N-alkylated isoxazolines. 3. Second is the reaction between nitrone and dihydrofuran. 4. This large allowance provides a lot of flexibility for nitrone handle or probe incorporation. 5. Cis-trans selectivity of the resulting nitrone is poor, however, yields are good to excellent. 6. Although the reaction is extremely fast, it faces problems in incorporating the nitrone into biomolecules through metabolic labeling. 7. Lythranidine is classified as an alkaloid and it contains a piperidine group that defines the synthesis of the structure via nitrone cycloaddition. 8. The synthesis of this compound can take 11 steps instead or 8 depending on if the reaction undergone is a nitrone cycloaddition. 9. Moreover, substitution on both the carbon and nitrogen atoms of the nitrone dipole, and acyclic and endocyclic nitrones are all tolerated. 10. In the nitrone cycoladdition synthesis, when the pyridine is reduced, it forms a cis product and the product wanted is trans.
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