MJD causes ophthalmoplegia and mixed sensory and cerebellar ataxia.
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Internuclear ophthalmoplegia is a disorder of conjugate lateral gaze.
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Ophthalmoplegia or the inability / difficulty to move the eye is usually symmetrical.
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Deep tendon reflexes are usually decreased or absent, and ophthalmoplegia and bulbar palsy can occur.
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It has been previously referred to as polyneuropathy, ophthalmoplegia, leukoencephalopathy, and POLIP syndrome.
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In fact, the progressive ophthalmoplegia is often unnoticed till decreased ocular motility limits peripheral vision.
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Other commonly reported symptoms include anterior pituitary dysfunction, visual field defects, headache / pain, and ophthalmoplegia.
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Limb and respiratory ( diaphragm ) muscles are especially affected . eye muscles may be weakened, leading to ophthalmoplegia.
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Lesions of the abducens nucleus and the MLF produce observable sixth nerve problems, most notably internuclear ophthalmoplegia ( INO ).
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The three most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, and pigmentary retinopathy.
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