Motoo Kimura's subsequent mathematical analyses reinforced what Crow had suggested in 1950 : that even if overdominant loci are rare, they could be responsible for a disproportionate amount of genetic variability.
2.
If overdominant loci are common, then a high level of heterozygosity would result from natural selection, and mutation-inducing radiation may in fact facilitate an increase in fitness due to overdominance . ( This was also the view of Dobzhansky .)
3.
Further collaboration between Crow and Kimura led to the infinite alleles model, which could be used to calculate the number of different alleles expected in a population, based on population size, mutation rate, and whether the mutant alleles were neutral, overdominant, or deleterious.
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