Its structure has a disubstituted oxadiazole skeleton, representing a new class of nematicides.
2.
In previous studies, it was found that oxadiazole, although cocaine-like in activity, exhibits a significantly longer duration of action due to slower rate of metabolism.
3.
Opicapone was designed as a hydrophilic 1, 2, 4-oxadiazole analogue with a pyridine N-oxide residue at position 3 to provide high COMT inhibitory potency and avoid cell toxicity.
4.
"' Furazan "', or 1, 2, 5-oxadiazole, is an aromatic organic compound consisting of a five-atom ring containing 1 oxygen and 2 nitrogen atoms.
5.
Drugs bind with the methylisoxazole ring close to the entrance pocket in VP1, the 3-fluromethyl oxadiazole ring at the end of the pocket and the phenyl ring in the center of the pocket.
6.
It acts as a CB 1 receptor agonist with a pK B value of 7.2 and demonstrates that replacing the ketone in 3-carbonylindoles with an oxadiazole spacer does generally not lead to activity loss.
7.
1, 2, 4-Oxadiazole, 1, 2, 5-oxadiazole, and 1, 3, 4-oxadiazole are known, but the 1, 2, 3-isomer is unstable ring-opens to form the diazoketone tautomer.
8.
1, 2, 4-Oxadiazole, 1, 2, 5-oxadiazole, and 1, 3, 4-oxadiazole are known, but the 1, 2, 3-isomer is unstable ring-opens to form the diazoketone tautomer.
9.
1, 2, 4-Oxadiazole, 1, 2, 5-oxadiazole, and 1, 3, 4-oxadiazole are known, but the 1, 2, 3-isomer is unstable ring-opens to form the diazoketone tautomer.
10.
The detector consisted of a tank filled with 167 tons ( 50, 000 gallons ) of mineral oil and of b-PDB ( 2-( 4-tert-butylphenyl )-5-( 4-biphenyl )-1, 3, 4-oxadiazole ) organic scintillator material.
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