phagolysosome sentence in Hindi
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- The phagosome then combines with a lysosome to create a phagolysosome.
- Within the phagolysosome, enzymes and toxic peroxides digest the pathogen.
- The fusion of lysosomes with the phagosome creates a phagolysosome . 3.
- These bacteria reside and multiply in macrophages, preventing formation of the phagolysosome to avoid degradation.
- In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium.
- The phagosome of ingested material is then fused with the lysosome, forming a phagolysosome and leading to degradation.
- As in phagocytic immune cells, the resulting phagosome may be merged with lysosomes containing digestive enzymes, forming a phagolysosome.
- Dysentery is caused when the bacteria escape the epithelial cell phagolysosome, multiply within the cytoplasm, and destroy host cells.
- During phagocytosis by macrophages, the promastigotes inhibit the formation of the phagolysosome, a cellular product by which invading pathogens are removed.
- Following internalization, the microbe is enclosed in a vesicular phagosome which then undergoes fusion with primary or secondary lysosomes, forming a phagolysosome.
- The amastigotes replicate in the most hostile part of the macrophage cell, inside the phagolysosome, whose normal defensive response they are able to prevent.
- For example, when a macrophage ingests a pathogenic microorganism, the pathogen becomes trapped in a phagosome which then fuses with a lysosome to form a phagolysosome.
- Phosphatidylinositol and Vps34-Beclin1 signalling pathways have been implicated to traffic the endocytosed phagosome to intracellular lysosomes, where fusion of the phagosome and the lysosome produces a phagolysosome.
- When granules fuse with a phagosome, myeloperoxidase is released into the phagolysosome, and this enzyme uses hydrogen peroxide and chlorine to create hypochlorite, a substance used in domestic bleach.
- The acidity of the phagolysosome is essential for " C . burnetii " to transport glucose, glutamate, proline and also for the synthesis of nucleic acids and proteins.
- In the Kupffer cells, most of the Gd 2 O 3 @ SWNHag was detected inside phagosomes, but some were in another cytoplasmic compartment that was most likely the phagolysosome.
- Activation of macrophages by IFN? from T h 1 helper cells in mycobacterial infections allows the macrophages to overcome the inhibition of phagolysosome maturation caused by mycobacteria ( to stay alive inside macrophages ).
- These organelles contain a plethora of degradative enzymes and antimicrobial peptides that are released into the phagolysosome, such as proteases, nucleases, phosphatases, esterases, lipases, and highly basic peptides.
- After diurnal disk-shedding and phagocytosis of outer segment by RPE cells, A2PE is hydrolyzed inside the RPE phagolysosome to form A2E . Accumulation of A2E causes toxicity at the primary RPE level and secondary photoreceptor destruction in macular degenerations.
- For example, following phagocytosis, the ingested particle ( or phagosome ) fuses with a lysosome containing hydrolytic enzymes to form a phagolysosome; the pathogens or food particles within the phagosome are then digested by the lysosome's enzymes.
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