1. The phagosome then combines with a lysosome to create a phagolysosome. 2. The fusion of lysosomes with the phagosome creates a phagolysosome . 3. 3. In addition, production of the diterpene isotuberculosinol prevents maturation of the phagosome . 4. Membrane fusion of the phagosome and lysosome is regulated by Rab 5 protein. 5. ATG13 is an autophagy factor required for phagosome formation. 6. Then, the bacteria is phagocytosized by the host cell and enveloped by a phagosome . 7. They grow and multiply inside the phagosome . 8. Upon release from the phagosome , the toxin has reduced activity in the more basic cytosol. 9. The bacteria also carry the " UreC " gene, which prevents acidification of the phagosome . 10. After LLO lyses the phagosome , the bacterium escapes into the cytosol, where it can grow intracellularly.
Mobile