Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.
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"' Phenacemide "'( analogue of phenytoin ( a hydantoin ), and is structurally related to the barbiturates and to other hydantoins.
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Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide, but is less toxic in comparison, despite still being a toxic drug.
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