phenacetin sentence in Hindi
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- These included acetanilide, phenacetin, and paracetamol ( acetaminophen ).
- The sales of phenacetin established Bayer as a leading pharmaceutical company.
- How phenacetin and other analgesics lead to this damage is incompletely understood.
- It contained 42 % aspirin, 42 % phenacetin, plus caffeine.
- Paracetamol was then quickly discarded in favor of phenacetin.
- Bayer chemists soon developed Phenacetin, followed by the sedatives Sulfonal and Trional.
- Kast was instrumental in introducing phenacetin and the sulphonal group of drugs into medicine.
- Together with Julius Axelrod, he discovered that acetanilide and phenacetin both metabolize to paracetamol.
- Chemically, it is similar to phenacetin with which it shares the risk of carcinogenesis.
- Von Mering claimed that, unlike phenacetin, paracetamol had a slight tendency to produce methemoglobinemia.
- Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.
- Due to low cost phenacetin is used for research into the physical and refractive properties of crystals.
- Paracetamol is the major metabolite of phenacetin and may contribute to kidney injury through a specific mechanism.
- However, unlike phenacetin, acetanilide and their combinations, paracetamol is not considered carcinogenic at therapeutic doses.
- A follow-up paper by Brodie and Axelrod in 1949 established that phenacetin was also metabolised to paracetamol.
- In the 1950s, Sp�hler and Zollinger reported an association between kidney injury and the chronic use of phenacetin.
- This condition was dubbed analgesic nephropathy and was attributed to phenacetin, although no absolute causative role was demonstrated.
- NSAIDs in combination with excessive use of phenacetin and / or paracetamol ( acetaminophen ) may lead to analgesic nephropathy.
- This was accompanied by the commercial demise of phenacetin, blamed as the cause of analgesic nephropathy and hematological toxicity.
- In most areas, its incidence has declined sharply since the use of phenacetin fell in the 1970s and 1980s.
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