picrotoxin sentence in Hindi
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- The protein also contains a number of different inhaled anaesthetics, and picrotoxin, among others.
- It is also toxic to mice and dogs, producing convulsant effects that are similar to those of picrotoxin.
- On the other hand, evidence exists that picrotoxin acts as a competitive antagonist, and not as a channel blocker.
- Strychnine is subcategorized as a convulsant along with picrotoxin and bicuculline, thought these convulsant inhibit GABA receptors instead of glycine.
- This could, for example, mean that picrotoxin enhances the occurrence of a desensitized state or an allosterically blocked state ."
- Its fruit, " Cocculus indicus ", is the source of picrotoxin, a poisonous alkaloid with stimulant properties.
- However, over time, the narrow therapeutic window associated with picrotoxin administration which can also induce seizures resulted in its disuse.
- They found that dilute intravenous solutions of picrotoxin ( cocculin )-- a neurostimulatory plant product were effective as an antidote in that setting.
- Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA A receptor-chloride channel complex at the picrotoxin binding site.
- Sesquiterpenes such as picrotoxin and diterpenes such as clerodane diterpene are also present, while the triterpenes are scarce and where present are similar to oleanane.
- In functional expression studies, TAS2R14 responds to ( " )-?-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries.
- It is a convulsant; it produces symptoms and has a mechanism of action similar to picrotoxin . ( Dioscorine is not to be confused with dioscorin, the yam storage protein .)
- For example, Newland and Cull-Candy ( 1992 ) found that when recording GABA-activated currents in neurons, picrotoxin " did not alter the amplitude of the main conductance state.
- Ts65Dn mice injected with a 2-week regimen of either of two compounds picrotoxin or bilobalide ( both GABA antagonists ) showed marked improvements in both exploration and recognition of novel objects over controls injected with only saline.
- These oscillations can be disrupted by GABA blocker picrotoxin, and the disruption of the oscillatory synchronization leads to impairment of behavioral discrimination of chemically similar odorants in bees and to more similar responses across odors in downstream ?-lobe neurons.
- However, picrotoxin did reduce the frequency of channel openings . " They concluded, " Our data are consistent with a mechanism whereby picrotoxin binds preferentially to an agonist bound form of the receptor and stabilizes an agonist-bound shut state.
- However, picrotoxin did reduce the frequency of channel openings . " They concluded, " Our data are consistent with a mechanism whereby picrotoxin binds preferentially to an agonist bound form of the receptor and stabilizes an agonist-bound shut state.
- "' Picrotoxin "', also known as "'cocculin "', is a poisonous crystalline plant compound, first isolated by the French pharmacist and chemist Pierre Fran�ois Guillaume Boullay ( 1777 1869 ) in 1812.
- Examples of such agents, some of which are used or have been used clinically for various purposes, and others of which are naturally occurring toxins, include strychnine, bemegride, flumazenil, cyclothiazide, flurothyl, pentylenetetrazol, bicuculline, cicutoxin, and picrotoxin.
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