1. The conversion of pregnenolone to progesterone takes place in two steps. 2. ACTH stimulates uptake of cholesterol and synthesis of pregnenolone . 3. To assay conversion of cholesterol to pregnenolone , radiolabelled cholesterol has been used. 4. Progesterone is prepared by the Oppenauer oxidation of pregnenolone . 5. It is formed from pregnenolone in the adrenal glands. 6. Pregnenolone product can be separated from cholesterol substrate using Sephadex LH-20 minicolumns.7. In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate. 8. In addition to allopregnanolone, exogenous pregnenolone also functions as a prohormone of pregnenolone sulfate. 9. The products range from sugar-free maple syrup to capsules of the steroid hormone pregnenolone . 10. In the human, the fetal adrenals produce dehydroepiandrosterone ( DHEA ) via the pregnenolone pathway.
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