1. All patients had previously not responded to an antiarrhythmic drug called procainamide . 2. Also it binds 10 % less to proteins than procainamide . 3. Procainamide , quinidine and disopyramide are Class Ia agents.4. Also procainamide -induced antinuclear antibodies are formed after a 6 months treatment. 5. Chemically, it is the " N "-acetylated metabolite of procainamide . 6. This substitution is the reason why procainamide exhibit a longer half-life time than procaine. 7. It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug. 8. Oral procainamide is no longer being manufactured in the US, but intravenous formulations are still available. 9. Procainamide is structurally similar to procaine but in place of an ester group contains procainamide an amide group.10. Procainamide is structurally similar to procaine but in place of an ester group contains procainamide an amide group.
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