proinsulin sentence in Hindi
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- Preproinsulin is a proinsulin molecule with a signal peptide attached to its N-terminus.
- In the RER the proinsulin folds into the correct conformation and 3 disulfide bonds are formed.
- -- Proinsulin is a precursor of insulin, which the body makes to convert sugar to energy.
- The signal peptide is cleaved as the polypeptide is translocated into lumen of the RER, forming proinsulin.
- When insulin was originally purified from bovine or porcine pancreata, all the proinsulin was not fully removed.
- This can be described as an iatrogenic injury due to slight differences between the proinsulin of different species.
- Proinsulin C-peptide was first described in 1967 in connection with the discovery of the insulin biosynthesis pathway.
- The signal sequence is cleaved from the N-terminus of the peptide by a signal peptidase, leaving proinsulin.
- Insulin resistance in Type 2 diabetes produces a greater demand for insulin production which results in the secretion of proinsulin.
- More modification can occur in the secretory vesicles ( for example insulin is cleaved from proinsulin in the secretory vesicles ).
- Another trend has been towards the use of more narrowly defined phenotypes, such as blood lipids, proinsulin or similar biomarkers.
- The team that she manages has specially studied the role of Proinsulin / insulin in the development of the central nervous system.
- Proinsulin is synthesized on membrane associated ribosomes found on the rough endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized.
- For the same reason, preproinsulin is rarely used medicinally, unlike insulin, the mature product, and proinsulin, a stable ER intermediate.
- In the pancreas, wolframin may help fold a protein precursor of insulin ( called proinsulin ) into the mature hormone that controls blood glucose levels.
- The endoproteases PC1 / 3 and PC2 aid in this transformation from proinsulin to insulin; and ( 3 ) the clathrin protein coat is removed.
- When the beta cell produces insulin from proinsulin, a connecting peptide ( or C-peptide ) is also manufactured and released into the bloodstream.
- Animal studies on cord lining EpSC have shown that genetic modifications using the proinsulin gene allowed transplanted stem cells to lower blood glucose levels in diabetic animals.
- About 5 10 min after its assembly in the endoplasmic reticulum, proinsulin is transported to the trans-Golgi network ( TGN ) where immature granules are formed.
- The C-peptide is abstracted from the center of the proinsulin sequence; the two other ends ( the B chain and A chain ) remain connected by disulfide bonds.
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