11. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle.12. In mammalian aldolase , the key catalytic amino acid residues involved in the reaction are lysine and tyrosine. 13. Compromised immunity has also been indicated, relating to the predominance or exclusivity of aldolase A in leukocytes. 14. Characterised as a recessive disorder, symptomatic presentation requires the inheritance of aldolase A mutations from both parents. 15. In particular this leads to a complication for clearly delineating the effects of enzymatic aldolase -A deficiency. 16. However, unlike in the primary instance parental aldolase activity was also partially reduced without significant physiological ailment. 17. In particular neurological impairment was conjecturally linked with the predominant role of aldolase A in the brain during development. 18. KDPG Aldolase was recently determined to be a trimer through crystallographic three-fold symmetry, with 225 residues. 19. Another part of the explanation was the presumed complexity of aldolase catalysis that dominated chemical thinking for a long time. 20. Plants and algae have plastidal aldolase , sometimes a relic of endosymbiosis, in addition to the usual cytosolic aldolase.
