11. The pharmacophore can be characterized as amphipathic , that means that the structure has both hydrophobic and hydrophilic groups. 12. A biological membrane is a kind of amphipathic layer that acts as a barrier within or around a cell. 13. The C-terminal amphipathic alpha helix is also the site of lacritin's only N-glycosylation site. 14. Epsin has an ENTH ( epsin N-terminal homology ) domain which inserts its amphipathic alpha helix into the membrane. 15. In one study, a short amphipathic peptide carrier, Pep-1, and protein complexes have proven effective for delivery. 16. Membrane association depends on a pleckstrin homology domain, as well as an amphipathic alpha-helical domain in the amino terminus. 17. Similar effects to melittin on H +-K +-ATPase have been found with the synthetic amphipathic polypeptide Trp-3. 18. The MBD amphipathic , with the alpha1 helix and the beta sheet lying parallel and the hydrophobic faces tightly packed against each other. 19. A helical wheel analysis shows that the membrane spanning alpha helices are amphipathic , with one side being polar and the other side hydrophobic. 20. Glutamine 106 resides within the amphipathic alpha helix near the C-terminus responsible for binding the N-terminus of syndecan-1.
