These iron-transporters can then be activated by known mammalian ferroxidases ( i . e . ceruloplasmin or hephaestin ).
12.
If a family history of liver disease is present, serum copper and ceruloplasmin levels can rule out Wilson's disease.
13.
Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.
14.
While the structure and kinetic activity of ceruloplasmin have been studied extensively, hephaestin has yet to be investigated at a similar level.
15.
The gene codes for a P-type ( cation transport enzyme ) ATPase that transports copper into bile and incorporates it into ceruloplasmin.
16.
The combination of neurological symptoms, Kayser Fleischer rings and a low ceruloplasmin level is considered sufficient for the diagnosis of Wilson's disease.
17.
The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin, and form a triangular as in that protein.
18.
An example of this is ceruloplasmin, a protein that functions as an oxidase in copper metabolism and moonlights as a copper-independent glutathione peroxidase.
19.
Hephaestin is a member of the family of copper oxidases that includes mammalian ceruloplasmin, yeast fet3 and fet5, and bacterial ascorbate oxidase, among others.
20.
Scheinberg and David Gitlin developed an inexpensive blood test to measure levels of ceruloplasmin in the blood, making the diagnosis of Wilson's disease easier.
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