11. This reaction is catalyzed by a cyclization domain on the Ser9 NRPS module. 12. This allows for easier cyclization via a protease or a protease-like enzyme. 13. As originally described, the Nazarov cyclization involves the activation of a mechanistic pathway. 14. Deprotection of compound 7 followed by cyclization and iodination results in vinyl iodide 8. 15. The cyclization of FPP proceeds via a synchronous reaction of trans-antiparallel additions. 16. The second step is an oxidative cyclization , and step 3 is an isomerization. 17. However, upon heating cyclization was observed and the reaction yielded NCAs and alkylchlorides. 18. The NCA method allows rapid cyclization to produce the target peptide with high yield. 19. Hundreds of steroids are found in plants, animals and cyclization of the triterpene squalene. 20. Their approach employed an aryne cyclization to close the final ring of the natural product.
