Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, S-100.
12.
It is classified by gene structure and coding sequence as a type III IF protein because of its homology with vimentin, GFAP and desmin.
13.
In adult muscle, desmin forms a scaffold around the Z-disk of the sarcomere and connects the Z-disk to the subsarcolemmal cytoskeleton.
14.
Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
15.
The condition now called Desmin-related myofibrillar myopathy ( also called myofibrillar myopathy-1 ) was formerly called inclusion body myopathy 1 ( IBM1 ).
16.
Diagnosis may be aided by immunostaining; endometrial stromal nodules are positive for CD10; leiomyomas are positive for caldesmon and desmin ( and sometimes CD10 ).
17.
A separate study examined this in more detail in cardiac tissue and found that murine hearts lacking desmin developed hypertrophic cardiomyopathy and chamber dilation combined with systolic dysfunction.
18.
There are three major domains to the desmin protein : a conserved alpha helix rod, a variable non alpha helix head, and a carboxy-terminal tail.
19.
Since desmin links the mitochondria to the sarcomere it may transmit information about contractions and energy need and through this regulate the aerobic respiration rate of the muscle cell.
20.
On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase.
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