Regarding extramedullary hematopoiesis, it's my understanding that minimal ( i . e . negligible ) hematopoiesis occurs in lymphoid tissue even in healthy adults.
12.
Bone marrow biopsies are performed to ensure the disease is localised; and in SPB or extramedullary plasmacytoma there will not be an increase of monoclonal plasma cells.
13.
Although these veins connect the trustworthy intramedullary and extramedullary veins, they have no support network to protect them and are seen in much fewer numbers by comparison.
14.
PET-CT may also be beneficial in detecting extramedullary tumours in individuals diagnosed with SPB . CT imaging may be better than plain film radiography for assessing bone damage.
15.
The result is extramedullary hematopoiesis, ie . blood cell formation occurring in sites other than the bone marrow, as the haemopoetic cells are forced to migrate to other areas, particularly the liver and spleen.
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