11. Hemolyzed hemoglobin is bound to a protein in plasma called haptoglobin , which is not excreted by the kidney. 12. Haptoglobin is produced mostly by hepatic cells but also by other tissues such as skin, lung and kidney.13. The protein involved is haptoglobin , which plays a role in cleaning up free radicals caused by high blood sugar. 14. Haptoglobin , in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges.15. This type of destruction does not release hemoglobin into the peripheral blood, so the haptoglobin cannot bind to it. 16. The trypanosome haptoglobin -hemoglobin receptor is an elongated three a-helical bundle with a small membrane distal head. 17. Other treatment possibilities include giving patients haptoglobin , a naturally occurring substance that clears hemoglobin from the body, he said. 18. Haptoglobin levels are low in malaria because of the haemolysis that occurs with the release of the merozoites into the blood.19. The rupture of the erythrocytes results in the release of free haem into the blood where it is bound by haptoglobin . 20. The association HPR with haemoglobin allows TLF-1 binding and uptake via the trypanosome haptoglobin -hemoglobin receptor ( TbHpHbR ).
