11. These channels may also function as a mitochondrial binding site for hexokinase and glycerol kinase. 12. It appears as if hexokinase possesses a single potential transmembrane domain located around amino acid 400. 13. But more recently it was suggested that inhibition of hexokinase activity leads to defects in glycolysis. 14. Mutations in the hexokinase gene can lead to a hexokinase deficiency which can cause nonspherocytic hemolytic anemia. 15. Mutations in the hexokinase gene can lead to a hexokinase deficiency which can cause nonspherocytic hemolytic anemia. 16. During the reaction phosphoglycerate kinase undergoes a substrate induced conformational change similar to another metabolic enzyme called hexokinase . 17. The first step of glycolysis is the phosphorylation of glucose by a hexokinase to form glucose 6-phosphate. 18. This reaction occurs due to the enzyme hexokinase , an enzyme that helps phosphorylate many six-membered ring structures. 19. In rats, it is also the predominant hexokinase in fetal tissues, likely due to their constitutive glucose utilization. 20. The digestion of many polysaccharides and glycoproteins yields mannose which is phosphorylated by hexokinase to generate mannose-6-phosphate.
