The prevalence of hypophosphatasia is not known; one study estimated the live birth incidence of severe forms to be 1 : 100, 000.
12.
Adult hypophosphatasia can be associated with rickets, premature loss of deciduous teeth, or early loss of adult dentation followed by relatively good health.
13.
In radiographic examinations, perinatal hypophosphatasia can be distinguished from even the most severe forms of osteogenesis imperfecta and mineralization; others have marked undermineralization and severe osteomalacia.
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