11. Ataxia is observed for lower ouabain concentrations, dystonia is observed at higher ouabain concentrations. 12. Additionally, the mammalian metabolism of rhamnose, the sugar component of ouabain , is unusual. 13. If ouabain was an endogenous hormone that contributed to hypertension, rostafuroxin would be expected to lower blood pressure. 14. NEM activates ouabain -insensitive Cl-dependent K efflux in low K sheep and goat red blood cells. 15. Ouabain did indeed inhibit the enzyme, thus establishing a link between the enzyme and the sodium-potassium pump.16. The positive properties of ouabain regarding the prophylaxis and treatment of these two indications are documented by a clutch of studies. 17. Indeed, an ouabain block of-pumps in the cerebellum of a live mouse results in it displaying ataxia and dystonia. 18. Recently, use of ouabain as a contraceptive has been investigated, showing that it can severely decrease the motility of spermatozoa. 19. Digoxin from the foxglove plant is used clinically, whereas bufalin and ouabain are used only experimentally due to their extremely high potency. 20. The consequence of the drugs actions are irreversible cell swelling and lysis ( e . g . ouabain at very high doses ).
