Pregnenolone is involved in a natural negative feedback loop against cannabis, from fully activating the CB 1
12.
Pregnenolone is then converted to progesterone that is secreted out of the cell and into the blood stream.
13.
This vicinal diol is then further oxidized with loss of the side chain starting at position C22 to produce pregnenolone.
14.
Lipoid CAH is one of the rarer forms of CAH and results from defects in the steps from cholesterol to pregnenolone.
15.
Pregnenolone stands poised to help fortify aging baby boomers in their quest to reclaim and sustain a sense of vitality and well-being.
16.
Fetal adrenal glands also produce pregnenolone in some species, which is converted into progesterone and estrogens by the placenta ( see below ).
17.
It catalyzes hydroxylation of 17?-hydroxyprogesterone to 11-deoxycortisol in the glucocorticoid pathway, which starts from pregnenolone and finishes with cortisol.
18.
It also catalyzes hydroxylation of progesterone to 11-deoxycorticosterone ( DOC ) in the mineralocorticoid pathway on its way from pregnenolone to aldosterone.
19.
Corticosterone has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone.
20.
Sripada et al . reported that oral pregnenolone is preferentially metabolized into the neurosteroid allopregnanolone rather than into other steroids such as DHEA or cortisol.
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