The Nobel committee cited Vane for discovering prostacyclin and carrying out detailed analyses of its biological effects and function.
12.
This intravenous prostacyclin relaxes blood vessels and buys an extra five years of life for about 60 percent of patients.
13.
The loss of this source of prostacyclin could help explain why women who have had hysterectomies are prone to cardiovascular problems.
14.
The 5-carbon ring of prostacyclin is conjoined to a second ring consisting of 4 carbon and one oxygen atom.
15.
Prostacyclin usually prevents platelet aggregation and vasoconstriction, so its inhibition can lead to excess clot formation and higher blood pressure.
16.
Apo A1 was also isolated as a prostacyclin ( PGI2 ) stabilizing factor, and thus may have an anticlotting effect.
17.
But like native prostacyclin, the structure of the epoprostenol molecule proved to be unstable in solution, prone to rapid degradation.
18.
The intravenous drug, called Flolan, or prostacyclin, buys an extra five years of life for about 60 percent of patients.
19.
Prostacyclin falls into a category of compounds known as prostaglandins, which help the cells defend against sudden changes from injury, disease or stress.
20.
Dysregulation of TXA synthase and an imbalance in the prostacyclin-thromboxane ratio are thought to underlie many pathological conditions, such as pulmonary hypertension.
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