Activated MMP7 and APMA can increase the activity of collagenase-1, and MMP7 can also convert the latent progelatinase A to its active form.
22.
In adrenocortical cells the trophic hormone ACTH induces expression of TIMP-1 and the increase in TIMP expression is also associated with decreased collagenase activity.
23.
A genetically engineered version of a hormone secreted in pregnancy that allows a woman's skin to stretch, Relaxin works by boosting collagenase and decreasing collagen.
24.
A study where patients were treated with these collagenase injections showed a recurrence rate of 67 % in the MCP joint and 100 % in the PIP joint.
25.
As skin cells age, for example, their genes churn out more and more collagenase, an enzyme that breaks down proteins needed to keep wrinkles at bay.
26.
Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell.
27.
Collagenase injection is a nonsurgical option to treat Dupuytren s disease and it provides the benefits of avoiding the potential surgical complications such as nerve injury, hematoma and skin necrosis.
28.
In February 2010 the US Food and Drug Administration ( FDA ) approved injectable collagenase extracted from " Clostridium histolyticum " for the treatment of Dupuytren's contracture.
29.
The main categories listed by the International Dupuytren Society in order of stage of disease are Radiation Therapy, Needle Aponeurotomy ( NA ), Collagenase Injection ( Xiaflex ) and Hand Surgery.
30.
Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn 341-Phe, Asp 441-Leu and Gln 354-Thr in the aggrecan interglobular domain
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