The first wave of epiblast cells to invaginate through the primitive streak invades and displaces the hypoblast to become the embryonic endoderm.
22.
Once the ICM has been established within the blastocyst, this cell mass prepares for further specification into the epiblast and primitive endoderm.
23.
The hypoblast contributes to extraembryonic membranes and the epiblast will give rise to the ultimate embryo proper as well as some extraembryonic tissues.
24.
In the mouse embryo, the egg forms a cylinder with the epiblast forming a cup at the distal end of that cylinder.
25.
The " Nodal " gene contains two enhancers : the Proximal Epiblast Enhancer ( PEE ) and the Asymmetric Enhancer ( ASE ).
26.
The epiblast gives rise to the fetus itself while the trophoblast develops into part of the placenta and the primitive endoderm becomes the yolk sac.
27.
A recent finding further showed that Foxd3 is necessary as a repressor in the transition from ESC to epiblast-like cells ( EpiLC ).
28.
Epiblast cells near the primitive streak form the neural plate and other dorsal structures, while the epiblast cells far from the streak become epidermis.
29.
Epiblast cells near the primitive streak form the neural plate and other dorsal structures, while the epiblast cells far from the streak become epidermis.
30.
These genomic alterations allow for the progressive specification of both epiblast and primitive endoderm lineages at the end of the blastocyst phase of development preceding gastrulation.
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