21. A weaker estrogen called estrone becomes the predominant form after menopause, when estradiol drops sharply. 22. Adipose tissue possesses aromatase, an enzyme that converts androstenedione to estrone and testosterone to estradiol. 23. Glucuronides are the most abundant estrogen conjugates and estrone glucuronide is the dominant metabolite of estradiol. 24. Woodward's doctoral work involved investigations related to the synthesis of the female sex hormone estrone . 25. Androstenedione transforms into estrone , while testosterone transforms into estradiol through the action of the enzyme aromatase. 26. It is the seco analogue of equilenin, while doisynolic acid is the seco analogue of estrone . 27. Estrone can be converted to estradiol, which is thought to be the major active estrogen in women.28. Premarin and estrone have been found to be equivalent in potency in an animal model of estrogenic activity. 29. Both dehydrogenation of estradiol by 17?-HSD into estrone and conjugation into estrogen conjugates are reversible transformations. 30. Some doctors and patients favor " bio-identical " estrogens _ estradiol, estrone and estriol.
