It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 ( PDE3 ) with positive inotropic and vasodilator effects.
22.
It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
23.
By increasing the concentration of intracellular calcium or increasing the sensitivity of receptor proteins to calcium, positive inotropic agents can increase myocardial contractility.
24.
Because of the negative inotropic effects, the nondihydropyridine calcium channel blockers should be avoided ( or used with caution ) in individuals with cardiomyopathy.
25.
PKA also phosphorylates components on myofilaments allowing actin and myosin to interact more easily and thus increasing contractility and the inotropic state of the heart.
26.
The measurement of the true gradient is accomplished by temporarily increasing the cardiac output by the infusion of positive inotropic agents, such as dobutamine.
27.
The primary antihypertensive mechanism of beta blockers is unclear, but may involve reduction in cardiac output ( due to negative chronotropic and inotropic effects ).
28.
For example, enlarged heart muscle ( ventricular hypertrophy ) can increase inotropic state, whereas dead heart muscle ( myocardial infarction ) can decrease it.
29.
Onmel / Sporanox ( Itraconazole ) exhibits a negative inotropic effect on the heart and thus could spur an additive effect when used concomitantly with Isradipine.
30.
T 1 AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.
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