Alpha-2-macroglobulin levels are increased in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins.
22.
A common variant ( 29.5 % ) ( polymorphism ) of alpha-2-macroglobulin leads to increased risk of Alzheimer's disease.
23.
The concentration of alpha-2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine.
24.
Each monomer of Human alpha-2-macroglobulin is composed of many functional domains, including macroglobulin domains, a thiol ester-containing domain and a receptor-binding domain.
25.
Each monomer of Human alpha-2-macroglobulin is composed of many functional domains, including macroglobulin domains, a thiol ester-containing domain and a receptor-binding domain.
26.
While the traditional PSA test measures the protein when it is bound chemically to the compound alpa1-antichymotrypsin or alpha2-macroglobulin, the new test measures levels of " free"
27.
The net result is that alpha-2-macroglobulin reaches serum levels equal to or greater than those of albumin in the nephrotic syndrome, which has the effect of maintaining oncotic pressure.
28.
Other macroglobulins include alpha-2 macroglobulin, which is elevated in nephrotic syndrome, diabetes, severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease.
29.
The normal version of A2M, which is short for alpha-2 macroglobulin, is one of the so-called " housekeeping genes " that cells need to keep their internal affairs orderly.
30.
PAK2 kinase activity is stimulated by transforming growth factor ? in fibroblasts, by proteinase inhibitor alpha2-macroglobulin binding to GRP78 in prostate cancer cells, by its phosphorylation by AMP-activated protein kinase in stem and cancer cells and eryptosis.
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