21. PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. 22. Its activation also induces mitogen -activated protein kinases ( MAPK ) activation along with Phosphoinositide 3-kinase activation. 23. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. 24. This gene encodes a protein involved in G protein-mitogen -activated protein kinase ( MAPK ) signaling cascades. 25. The protein encoded by this gene is a member of the MAP ( mitogen -activated protein ) kinase family. 26. Results showed that participants scoring high on hardiness had significantly higher mean antigen-and mitogen -induced proliferative responses. 27. Activation of members of the mitogen -activated protein kinase family is a major mechanism for transduction of extracellular signals. 28. Similar to phytohemagglutinin ( PHA ), it is a selective T cell mitogen relative to its effects on B cells. 29. A second pathway contributing to cell survival occurs through activation of the mitogen -activated protein kinase ( MAPK ) kinase. 30. Cimetidine was reported to be effective because of its depressing mitogen -induced lymphocyte proliferation and regulatory T cell activity features.
