21. The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. 22. Direct effects of chronic alcoholism are apparent in osteoblasts, osteoclasts and osteocytes. 23. At the same time, it has a direct effect on osteoclast activity. 24. TRAP substrates, which bind to osteoclasts when phosphorylated. 25. Occasional osteoclast -like giant multinucleated cells are encountered particularly at the periphery. 26. Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts. 27. Osteoclasts move in to reabsorb dead bone ends and other necrotic tissue are removed.28. Once activated, osteoclasts move to areas of microfracture in the bone by chemotaxis. 29. Osteoclasts are usually found grouped in the small pits on bone surfaces called lacunae.30. This reabsorption process can sometimes take up to weeks for the osteoclast to complete.
