At least two isoforms of mammalian arginase exists ( types I and II, this enzyme ) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.
32.
In 1904, two Germans A . Kossel and H . D . Dakin had shown that arginine could be hydrolysed by the enzyme arginase to form ornithine and urea in inorganic reaction.
33.
In most mammals, two isozymes of this enzyme exist; the first, Arginase I, functions in the urea cycle, and is located primarily in the cytoplasm of the liver.
34.
Researchers believe that buildup of arginine triggers increased expression of arginase II . The enzymes in the kidney will then catalyze ureagenesis, compensating somewhat for a decrease in arginase I activity in the liver.
35.
Researchers believe that buildup of arginine triggers increased expression of arginase II . The enzymes in the kidney will then catalyze ureagenesis, compensating somewhat for a decrease in arginase I activity in the liver.
36.
The " ARG1 " gene provides instructions for making an enzyme called arginase, this enzyme controls the last steps of the urea cycle, which produces urea by extracting nitrogen from arginine.
37.
Arginase, which catalyses the conversion of arginine to urea and ornithine, is one of the five members of the urea cycle enzymes that convert ammonia to urea as the principal product of nitrogen excretion.
38.
In people with arginase deficiency, arginase is missing, and arginine is not broken down properly . consequently, urea cannot be produced and excess nitrogen accumulates in the blood in the form of ammonia.
39.
In people with arginase deficiency, arginase is missing, and arginine is not broken down properly . consequently, urea cannot be produced and excess nitrogen accumulates in the blood in the form of ammonia.
40.
He studied chemistry at the University of Leeds with Julius B . Cohen and after he worked with Albrecht Kossel on arginase at the University of Heidelberg he joined Columbia University in 1905, working in the lab of Christian Herter.
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