31. Davis participated in breakthrough proof-of-concept studies and clinical trials of cholinesterase inhibitors. 32. It is a corrosive, and as a cholinesterase inhibitor, highly toxic through dermal absorption. 33. The effects of hexaethyl tetraphosphate on the cholinesterase of rat and cockroach tissue have been tested. 34. Glycopyrrolate, as a muscarinic receptor antagonist, may reduce the side effects of cholinesterase inhibitors. 35. It covalently binds by its phosphate group to serine group at the active site of the cholinesterase . 36. The new theory concerns a family of chemicals called cholinesterase inhibitors that short-circuit some nerve signals. 37. Sarin acts on cholinesterase by forming a covalent bond with the particular serine residue at the active site. 38. It is very similar to the neuronal acetylcholinesterase, which is also known as RBC or erythrocyte cholinesterase . 39. Compounds which function as competitive or noncompetitive inhibitors of cholinesterase are those most likely to have therapeutic uses. 40. Persons who work closely with naled or other organophosphate pesticides should undergo regular testing of their cholinesterase levels.
