At one time, fairly early in the research for diabetes treatment by transplantation, Ficoll was used in an attempt to separate islets of Langerhans from enzyme ( collagenase ) digested human pancreatic tissue.
32.
With respect to the role of GIP in lipid metabolism, supraphysiological levels have shown a lipogenic action, however the action of collagenase in experimental protocols is known to degrade GIP / GIP receptors.
33.
Another study showed that release of HS-bound basic FGF in culture could be achieved through treatment with stromelysin, heparitinase I, rat collagenase and plasmin, and these proteolysis sites are illustrated in figure 1.
34.
Collagenase clostridium histolyticum ( marketed as Xiaflex by [ Auxilium ] ), a drug originally approved by the FDA to treat Dupuytren's contracture, is now an FDA approved injectable drug for treatment of Peyronie's disease.
35.
Papain as well as other proteases, including bromelain, collagenase, trypsin and thermolysin, have also been tried or used according to other reports on the use of proteases for debridement of wounds and burns without damaging healthy tissue.
36.
Certain MMPs including MMP-1, MMP-2, MMP-8, MMP-13, and MMP-14 have collagenase activity, meaning that, unlike many other enzymes, they are capable of degrading collagen I fibrils.
37.
:Cleavage of Asn 3-Gln, His 10-Leu and Ala 14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase
38.
The human MMP7 is located on chromosome 11 q22.3 . " MMP " genes are clustered in q region of human Chromosome 11 including " matrilysin, collagenase-1, stromelysin1, stromelysin-2, and metalloelastase " genes.
39.
During the early proliferative phase ( 0 12 months ) the tumors express proliferating cell nuclear antigen ( pericytesna ), vascular endothelial growth factor ( VEGF ), and type IV collagenase, the former two localized to both endothelium and pericytes, and the last to endothelium.
40.
VR-RNA regulates the toxin colA ( collagenase ) by base-pairing to colA mRNA, the 3'end of VR-RNA base-pairs to a region in the 5'UTR of the colA mRNA . This induces cleavage of the colA mRNA in the 5'UTR and leads to stabilisation of the mRNA and increased translation.
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