In particular, she is involved in researching a phenomenon where the corpus collosum is absent ( agenesis ) or disformed ( dysgenesis ) in the developing brain.
32.
The observable characteristics ( phenotype ) of this condition are highly variable, ranging from gonadal dysgenesis in males, to Turner-like females and phenotypically normal males.
33.
Blood tests for alpha-fetoprotein, karyotype, human chorionic gonadotropin, and liver function are used to diagnose germ cell tumor and potential co-occurring gonadal dysgenesis.
34.
Hybrid dysgenesis manifests when crossing P strain males with M strain females and not when crossing P strain females ( females with autonomous P elements ) with M strain males.
35.
Although MRI can detect the absence of a cervix ( agenesis ), it is unable to show cervical dysgenesis ( where the cervix is present, but malformed ).
36.
In the 1950s, endocrinologists developed a basic understanding of the major intersex conditions such as congenital adrenal hyperplasia ( CAH ), androgen insensitivity syndrome, and mixed gonadal dysgenesis.
37.
In addition to agenesis of the corpus callosum, similar conditions are hypogenesis ( partial formation ), dysgenesis ( malformed ), and hypoplasia ( underdevelopment, including too thin ).
38.
For this reason, in gonadal dysgenesis the accompanying hormonal failure also prevents the development of secondary sex characteristics in either sex, resulting in a sexually infantile female appearance and infertility.
39.
The most common cause is low levels of estrogen ( hypoestrogenism ), which may result from chronic disease, radiation or chemotherapy, Poland syndrome, extreme physical activity, or gonadal dysgenesis.
40.
Maternal viral infections, embryonic trauma, teratogenic environmental exposures or vascular dysgenesis ( failure of the embryo to form a satisfactory blood supply ) between four and seven weeks gestation are considered possible causes.
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