31. The ? isoform is expressed in human endothelium . 32. It is also found in the endothelium cells of the blood-brain barrier. 33. NO is also responsible for endothelium -derived relaxing factor activity regulating blood pressure. 34. It is expressed as early as embryonic day 9.5 in the endothelium . 35. KLF2 then has four key functions in endothelium : 36. The disease is manifested by an abnormal proliferation of lymphoid follicles and vascular endothelium . 37. Patients with CES suffer from compromised corneal endothelium resulting from chronic hypoxia and acidosis. 38. They also express receptors to detect and adhere to endothelium and Fc receptors for opsonin. 39. The endothelium activation is considered type II since gene induction and protein synthesis are involved. 40. During surgery the patient's corneal endothelium is removed and replaced with donor tissue.