The epiblast in that region moves down into the streak at the location of the primitive pit where the process called differentiate into various cell types.
32.
The epiblast has now differentiated into the three germ layers of the embryo, so that the bilaminar disc is now a trilaminar disc, the gastrula.
33.
The hypoblast is pushed out of the way and goes on to form the amnion . The epiblast keeps moving and forms a second layer, the mesoderm.
34.
When " Cul4b " deletion was limited to the epiblast ( only in Sox2-expressing tissue ), it was possible to generate living mice.
35.
Upon commencement of gastrulation, the primitive streak, a visible, morphological groove, appears on the posterior epiblast and orients along the anterior-posterior embryo axis.
36.
Furthermore, GATA-6 has been linked to the production of LIF, a cytokine that encourages proliferation of endodermal embryonic stem cells and blocks early epiblast differentiation.
37.
They determined that cells move to the center of the epiblast following the activation of the Wnt planar cell polarity pathway by fibroblast growth factors made by the hypoblast.
38.
In the epiblast, it is induced by the primitive streak through Wnt signaling, and produces endoderm and mesoderm from a transitory tissue called mesendoderm during the process of gastrulation
39.
Underlying the epiblast is the hypoblast, where the extra-embryonic tissue originates . suggesting that its presence is important for regulating the formation of a single primitive streak.
40.
The epiblast is the outer layer that consists of columnar cells . The inner layer is called the hypoblast, or primitive endoderm, which is composed of cuboidal cells.
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