31. On July 10, 2007 Manhattan Pharmaceuticals announced that its phase 2a studies for oral oleoyl-estrone failed. 32. About 15 % of orally administered estradiol is converted into estrone and 65 % is converted into estrone sulfate. 33. About 15 % of orally administered estradiol is converted into estrone and 65 % is converted into estrone sulfate. 34. Bioidentical estradiol ( estrogen ) when taken orally is converted in the liver to estrone , a weaker bioidentical estrogen. 35. This is significant because less benzestrol could be used to produce the same effect as estrone in increasing estrogen production. 36. Then, placental 17?-hydroxysteroid dehydrogenase interconverts estrone and estradiol and the two hormones are secreted into the maternal circulation. 37. These concentrations of estradiol and estrone are comparable to those observed with 1 and 2 mg / day oral micronized estradiol. 38. In the diagram, Part A represents the successful conversion of androstenedione and testosterone into estrone and estradiol in the liver. 39. E2S can also be metabolized into estrone sulfate ( E1S ), which in turn can be converted into estrone and estradiol. 40. E2S can also be metabolized into estrone sulfate ( E1S ), which in turn can be converted into estrone and estradiol.
