31. This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation . 32. Six hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatin III. 33. Deacetylvindoline is the product of a hydroxylation of desacetoxyvindoline by deacetoxyvindoline 4-hydroxylase ( D4H ). 34. Two of the most commonly proposed mechanisms used for the hydroxylation of an sp3 C-H bond. 35. The hydroxylation of HIF1A proline residue also regulates its ability to associate with co-activators under hypoxia. 36. Dopamine beta-hydroxylase catalyzes the hydroxylation of not only dopamine but also other phenylethylamine derivatives when available. 37. This outcome is the opposite of that of the related Woodward cis-hydroxylation which gives syn addition. 38. The hydroxylation of tomatine likely leads to the formation of tomatidine, which is the aglycon of tomatine. 39. The common modifications include glycosylation, phosphorylation, ubiquitination, sulfation, methylation, acetylation, and hydroxylation . 40. Hence, the hydroxylation of proline is a critical biochemical process for maintaining the connective tissue of higher organisms.
