Control of the pathogen ( antifungal medication ) now relies on the application of azole fungicides which are demethylase inhibitors that inhibit lanosterol 14 alpha-demethylase ( CYP51 ) activity.
32.
The extra carbon in the furan ring at C-4 comes from the 3-position of mevalonic acid and represents the C-4?-methyl group of lanosterol.
33.
They are induced by the corticosteroid cortexolone and by phenanthrene . " C . elegans " also possesses a lanosterol 14-alpha demethylase, another enzyme in the cytochrome P450 family.
34.
"' Lanosterol synthase "'is an oxidosqualene cyclase ( OSC ) enzyme that converts ( S )-2, 3-oxidosqualene to a protosterol cation and finally to lanosterol.
35.
"' Lanosterol synthase "'is an oxidosqualene cyclase ( OSC ) enzyme that converts ( S )-2, 3-oxidosqualene to a protosterol cation and finally to lanosterol.
36.
In the biosynthesis of viridiol by " Gliocladium deliquescens ", the 3?-OH reduced form of viridin, the incorporation of squalene, lanosterol, dehydroxydemethoxyviridin, and demethoxyviridin was reported.
37.
Directed evolution and protein design have been used to identify small numbers of point mutations that alter the product specificities of OSC enzymes, most notably in altering a cycloartenol synthase to produce predominantly lanosterol.
38.
The enzyme-catalyzed demethylation of lanosterol is believed to occur in three steps, each of which requires one molecule of diatomic oxygen and one molecule of NADPH ( or some other reducing equivalent ).
39.
Miconazole, itraconazole, and clotrimazole work in a different way, inhibiting synthesis of ergosterol from lanosterol by interfering with inhibit the enzyme that performs these demethylation steps in the biosynthetic pathway between lanosterol and ergosterol.
40.
Miconazole, itraconazole, and clotrimazole work in a different way, inhibiting synthesis of ergosterol from lanosterol by interfering with inhibit the enzyme that performs these demethylation steps in the biosynthetic pathway between lanosterol and ergosterol.
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