First, P-selectin is synthesized by megakaryocytes and endothelial cells, where it is sorted into the membranes of secretory granules.
32.
The first KLF, KLF1, originally known as Erythroid KLF ( EKLF ) is expressed only in red blood cells and megakaryocytes.
33.
MiR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.
34.
"' MegaCult "'is a collagen-based medium for the growth, detection and quantification of megakaryocyte progenitors.
35.
They are the functional equivalents of platelets, but circulate as intact mononuclear cells, and are not simply cytoplasmic fragments of bone marrow megakaryocytes.
36.
When megakaryocytes and endothelial cells are activated by agonists such as thrombin, P-selectin is rapidly translocated to the plasma membrane from granules.
37.
Thrombopoietin is bound to the surface of platelets by the mpl receptor ( CD 110 ) and destroyed, thereby reducing megakaryocyte exposure to the hormone.
38.
In preclinical human trials mature megakaryocytes which develop during " in vivo " treatment with Neumega were ultrastructurally, morphologically, and functionally normal.
39.
Thrombopoietin regulates the differentiation of megakaryocytes and platelets, but studies on the removal of the thrombopoietin receptor show that its effects on hematopoiesis are more versatile.
40.
Low platelets lead a higher degree of thrombopoietin exposure to the undifferentiated bone marrow cells, leading to differentiation into megakaryocytes and further maturation of these cells.
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