31. For instance, PTH also indirectly stimulates osteoclasts . 32. Osteoclasts are large, multinucleated bone cells that conduct the process of bone resorption.33. Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatology disorders.34. Inhibition of the expression of " mTOR " can stop osteoclast activity. 35. As osteoclasts break down bone, patients see a loss of bone mineral density. 36. Activation of RANK by RANKL promotes the maturation of pre-osteoclasts into osteoclasts. 37. Activation of RANK by RANKL promotes the maturation of pre-osteoclasts into osteoclasts . 38. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. 39. Bone erosion caused by mature osteoclast cells is common in patients with rheumatoid arthritis. 40. Normally, bone removed by osteoclasts is replaced quickly by other cells, the osteoblasts.
