Phosphatidylinositol and Vps34-Beclin1 signalling pathways have been implicated to traffic the endocytosed phagosome to intracellular lysosomes, where fusion of the phagosome and the lysosome produces a phagolysosome.
32.
These gold nanoshells are shuttled into tumors by the use of phagocytosis, where phagocytes engulf the nanoshells through the cell membrane to form an internal phagosome, or macrophage.
33.
It has been found to be important in phagosome maturation and in reducing the number of intracellular mycobacteria with the help of other mitochondrial fission proteins such as DRP1 and FIs1.
34.
When granules fuse with a phagosome, myeloperoxidase is released into the phagolysosome, and this enzyme uses hydrogen peroxide and chlorine to create hypochlorite, a substance used in domestic bleach.
35.
In addition, the " B . suis " gene for nickel transport, " nikA ", is activated by metal ion deficiency and is expressed once in the phagosome.
36.
Once inside the macrophage, " B . suis " is able to endure the rapid acidificiation in the phagosome to pH 4.0-4.5 by expressing metabolism genes mainly for amino acid synthesis.
37.
For example, following phagocytosis, the ingested particle ( or phagosome ) fuses with a lysosome containing hydrolytic enzymes to form a phagolysosome; the pathogens or food particles within the phagosome are then digested by the lysosome's enzymes.
38.
For example, following phagocytosis, the ingested particle ( or phagosome ) fuses with a lysosome containing hydrolytic enzymes to form a phagolysosome; the pathogens or food particles within the phagosome are then digested by the lysosome's enzymes.
39.
This structural characteristic allows for " B . suis " to interact with lipid rafts on the surface of macrophages to be internalized, and the formed lipid-rich phagosome is able to avoid fusion with lysosomes through this endocytic pathway.
40.
According to another study ( done by some of the same people cited at the bottom of paragraph 1 of this section ), as the phagosome forms or soon after it forms, it fuses with the ER to form an ER-phagosome mix compartment.
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