These genes are ancient, being pleiotropic reuse explains why these genes are highly conserved, as any change would have many adverse consequences which natural selection would oppose.
32.
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication.
33.
In all, thousands of genes are activated by TLR signaling, and collectively, the TLRs constitute one of the most pleiotropic yet tightly regulated gateways for gene modulation.
34.
Lethal white syndrome has been described by researchers as both pleiotropic conditions, such as lethal white syndrome, the application of " recessive " or " dominant " can be ambiguous.
35.
It is a highly pleiotropic disorder that clinically manifests by form of short-limbed dwarfism due to skeletal dysplasia, variable level of immunodeficiency and predisposition to malignancies in some cases.
36.
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system.
37.
:: Yes, I suspect it's a pleiotropic effect, it is probably a side effect of the fact that the person has lots of body hair for some reason.
38.
NFAT is a transcription factor that activates the transcription of a pleiotropic set of genes, most notable, IL-2, a cytokine that promotes long-term proliferation of activated T cells.
39.
FGL2 is a protein that exhibits pleiotropic effects within the body and is an important immune regulator of both endothelial cells and can be constitutively secreted by both CD4 + and CD8 + T cells.
40.
Andrzej Pkalski, from the University of WrocBaw, argues that eugenics can cause harmful loss of genetic diversity if a eugenics program selects for a pleiotropic gene that is also associated with a positive trait.
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