31. The enzyme then utilizes a histidine residue to remove the phosphate group from succinyl phosphate and generate succinate . 32. Succinate -semialdehyde dehydrogenase is found in organisms ranging across the tree of life from bacteria to humans.33. :thebaine + 2-oxoglutarate + O 2 \ rightleftharpoons neopinone + formaldehyde + succinate + CO 2 34. :codeine + 2-oxoglutarate + O 2 \ rightleftharpoons morphine + formaldehyde + succinate + CO 2 35. The excess succinate abnormally stabilizes hypoxia-inducible factors ( HIF ), which also builds up in cells. 36. SCS facilitates the flux of molecules into other metabolic pathways by controlling the interconversion between succinyl CoA and succinate . 37. Type A says oxide & carbonate; type B says oxide, citrate, fumarate, malate, succinate . 38. Zafatek is administered in the form trelagliptin succinate in a 1 : 1 mixture of trelagliptin and succinic acid. 39. Fumarate and succinate have been identified as potent inhibitors of prolyl hydroxylases, thus leading to the stabilisation of HIF. 40. Succinate -analogue inhibitors include the synthetic compound malonate as well as the TCA cycle intermediates, malate and oxaloacetate.
