1. Succinate accumulation caused by SDH inactivation inhibits the prolyl hydroxylase EglN3.2. SdhA provides the binding site for the oxidation of succinate . 3. Little is known about the exact succinate oxidation FAD accepts the hydride. 4. Succinate competes with ?-ketoglutarate in binding to the PHD enzyme.5. It may be prepared by thermal decomposition of ammonium succinate 6. The build-up of succinate inhibits PHD activity. 7. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. 8. A step with significant variability is the conversion of succinyl-CoA to succinate . 9. Further research is required to determine which elimination mechanism succinate undergoes in Succinate Dehydrogenase. 10. Further research is required to determine which elimination mechanism succinate undergoes in Succinate Dehydrogenase.
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